Synthesis of functionalised organochalcogenides and in vitro evaluation of their antioxidant activity

Differently substituted β-hydroxy- and β-amino dialkyl alkyl-aryl tellurides selenides have been prepared through ring-opening reactions of epoxides aziridines with selenium- or tellurium-centered nucleophiles. The antioxidant properties the cytotoxicity such compounds investigated on normal human dermal fibroblasts. Most studied exhibited a low number them proved to be non-toxic, not showing any effect cell viability even at highest concentration used (100 μM). obtained results showed significant potential selected organotellurium compounds, particularly evident under conditions exogenously induced oxidative stress. activity selenium-containing analogues active has also evaluated cells, highlighting that replacement Se Te brought about increase in peroxidase activity.